Women’s Skin Complex (4-in-1)
- Product overview
- Why Tretinoin
- How it works
- Treatment process
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- Why REG3N
- Common questions
- Treatment information
Estriol/Finasteride/Tretinoin with Niacinamide
From $65/mo*
A 4-in-1 topical cream combining estriol, finasteride, tretinoin, and niacinamide to target visible signs of aging.
*Billed quarterly with a three-month commitment paid up front.
WHY TRETINOIN
Increases skin cell turnover. Improves photoaged skin.
Supports sun-damaged skin
In a 6-month trial of nearly 300 adults with sun-damaged skin, 68% using tretinoin showed overall skin improvement.
Source: Olsen et al., "Tretinoin Emollient Cream: A New Therapy for Photodamaged Skin," Journal of the American Academy of Dermatology (1992) & Stern, "Treatment of Photoaging," New England Journal of Medicine (2004)
Published study facts
Helps reduce fine wrinkles
The trial found tretinoin was effective at reducing fine wrinkles, uneven brown spots (mottled hyperpigmentation), and rough skin texture.
Source: Olsen et al., "Tretinoin Emollient Cream: A New Therapy for Photodamaged Skin," Journal of the American Academy of Dermatology (1992) & Stern, "Treatment of Photoaging," New England Journal of Medicine (2004)
Demonstrates 2x improvements
Across multiple similar trials, the rate of improvement with tretinoin was roughly double that of placebo.
Source: Olsen et al., "Tretinoin Emollient Cream: A New Therapy for Photodamaged Skin," Journal of the American Academy of Dermatology (1992) & Stern, "Treatment of Photoaging," New England Journal of Medicine (2004)
Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of a medication class or active ingredient. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes. References to medication classes, mechanisms, or published studies are intended to illustrate general pharmacologic concepts and do not establish that any specific medication, formulation, or treatment program will produce identical results. Compounded medications are not evaluated by the FDA for safety, quality or efficacy.
HOW WOMEN’S SKIN COMPLEX WORKS
Rebuilds collagen.
Improves skin texture. Tretinoin switches on genes responsible for producing collagen and regulating pigmentation. Niacinamide evens tone at the surface. Estriol hydrates the skin and increases elasticity. Finasteride blocks DHT, minimizing unwanted facial hair.
Accelerates cell turnover
Dead skin cells shed faster. New cells reach the surface more quickly, improving texture and tone.
Strengthens and restores skin
Estriol supports hydration and elasticity, while niacinamide strengthens the skin barrier, reduces redness, and brightens tone.
Stimulates collagen production
Fibroblasts are activated to produce new collagen, partially reversing structural damage from UV exposure.
Step 1
Medical intake
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A few minutes
Step 2
Doctor review
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*
Within 72 hours
Step 3
Fast shipping
Approved medications ship directly to your door in discreet packaging.
2-5 business days
Step 4
Unlimited messaging
Your doctor is available via chat any time for additional support. Video consults available. The same prescription framework as REG3N's medical team. *Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
Up to 12 months
Proactive care
Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.
Transparent pricing
No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.
Board-certified doctors
Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.
Curated by longevity experts
Every protocol is built by medical experts, based on longevity research from REG3N's science team.
What is Women’s Skin Complex?
Women’s Skin Complex is a topical cream containing estriol, finasteride, tretinoin, and niacinamide. It targets fine lines, uneven skin texture, and unwanted hair growth.
How do you use Women’s Skin Complex?
Cleanse skin thoroughly and pat dry. Apply a pea-sized amount of Women’s Skin Complex (4-in-1) to face and neck, focusing on areas of concern. Use once daily in the evening. Tretinoin increases sensitivity to the sun. Always follow with a broad-spectrum sunscreen during the day.
What are the side effects of Women’s Skin Complex?
Common side effects include mild redness or irritation, dryness, peeling, burning, and sun sensitivity. These effects are typically temporary and should fade as your skin grows accustomed to treatment.
Who shouldn’t use Women’s Skin Complex?
Women’s Skin Complex is not intended for use in men. Women’s Skin Complex may not be suitable for women who are pregnant, breastfeeding, or those with hormone-sensitive conditions. Your doctor will evaluate whether Women’s Skin Complex (4-in-1) is appropriate for you.
Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program.
A 4-in-1 topical cream combining estriol, finasteride, tretinoin, and niacinamide to target visible signs of aging.