Sermorelin (Injections)
- Product overview
- Why Ghrh Agonists
- How it works
- Treatment process
- Explore other treatments
- Why REG3N
- Common questions
- Treatment information
From $119/mo*
An experimental peptide protocol. Stimulates the pituitary gland’s natural release of growth hormone. This can support fat loss and muscle gain.
*Billed quarterly with a three-month commitment paid up front.
WHY GHRH AGONISTS
Growth hormone declines with age. GHRH agonists help restart the signal.
Growth hormone slows with age
Growth hormone (GH) production declines ~14% per decade after age 30. The driver is declining GHRH output, not pituitary failure. Because the pituitary remains responsive, reintroducing the GHRH signal can restart GH production.
Source: Melmed S, NEJM (2019); Aimaretti et al., J Endocrinol Invest (2008)
May increase IGF-1 and support body composition
In a trial of 22 healthy men aged 53 to 68, GHRH doubled IGF-1, increased lean mass, and reduced abdominal fat. Sermorelin is a shorter peptide in the same drug class that acts on the same receptor. While both stimulate the body's own GH production, sermorelin has not been tested in identical large-scale trials.
Source: Veldhuis et al., Journal of Clinical Endocrinology and Metabolism (2004)
Published study facts
May help restore GH and IGF-1 toward youthful levels
In a comparison of older and younger men, 14 days of GHRH injections brought the older men's growth hormone and IGF-1 back up to youthful levels.
Source: Corpas et al., Journal of Clinical Endocrinology and Metabolism (1992)
Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of a medication class or active ingredient. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes. References to medication classes, mechanisms, or published studies are intended to illustrate general pharmacologic concepts and do not establish that any specific medication, formulation, or treatment program will produce identical results. Compounded medications are not evaluated by the FDA for safety, quality or efficacy.
HOW SERMORELIN WORKS
Stimulates natural growth hormone release.
Sermorelin prompts your pituitary gland to release growth hormone, supporting muscle growth, fat loss, sleep, and recovery.
Signals pituitary gland
Sermorelin acts on cells in the pituitary gland, mimicking signals your body naturally sends to release growth hormone.
Supports metabolism
Growth hormone circulates to the liver, where it stimulates IGF-1 production. They work together to support increased muscle mass, fat loss, sleep, recovery, and tissue repair.
Releases growth hormone
The pituitary releases your body's own growth hormone in its natural rhythm of pulses, the on-off pattern your body is designed to respond to.
Step 1
Medical intake
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A few minutes
Step 2
Doctor review
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*
Within 72 hours
Step 3
Fast shipping
Approved medications ship directly to your door in discreet packaging.
2-5 business days
Step 4
Unlimited messaging
Your doctor is available via chat any time for additional support. Video consults available. The same prescription framework as REG3N's medical team. *Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
Up to 12 months
Proactive care
Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.
Transparent pricing
No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.
Board-certified doctors
Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.
Curated by longevity experts
Every protocol is built by medical experts, based on longevity research from REG3N's science team.
What is sermorelin?
Sermorelin is a peptide similar in structure to growth hormone-releasing hormone (GHRH). It signals the pituitary gland to release growth hormone in its natural, rhythmic pulses. It’s important to note that sermorelin is an experimental longevity treatment, and your doctor will likely recommend monitoring biomarker signals for safe administration.
How do you take sermorelin?
Sermorelin is typically administered at night, before bed, to align with your body's natural growth hormone pulse during deep sleep. Inject 15 to 30 units of sermorelin into the skin each night on 5 nights of the week. Inject on an empty stomach.
What are the side effects of sermorelin?
Side effects may include injection site reactions, antibody development, joint pain, facial flushing, and nausea.
Who shouldn’t take sermorelin?
Not recommended for people who are pregnant or breastfeeding, or people with a current or past diagnosis of cancer. Your doctor will evaluate whether sermorelin is appropriate for you.
Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program.
An experimental peptide protocol. Stimulates the pituitary gland’s natural release of growth hormone. This can support fat loss and muscle gain.