Daily Tadalafil (Generic for Cialis®)
- Product overview
- Why Tadalafil
- How it works
- Treatment process
- Explore other treatments
- Why REG3N
- Common questions
- Treatment information
Generic for Cialis®
From $24/mo*
Can help relax blood vessels, supporting sexual function, vascular health, and healthy aging.
*Billed quarterly with a three-month commitment paid up front.
WHY TADALAFIL
Blood vessels tighten as you age. Tadalafil helps keep them open.
May lower early death risk
A study of over 29,000 men found tadalafil users had a 44% lower risk of dying from any cause compared to non-users. Groups were matched for blood pressure, diabetes, and cholesterol medications.
Source: Kloner et al., "The Association of Tadalafil Exposure With Lower Rates of Major Adverse Cardiovascular Events and Mortality," Clinical Cardiology (2024)
Can reduce major heart events
Tadalafil users had 19% fewer major cardiovascular events — including heart attacks, strokes, and heart failure — and a 55% lower risk of dying from a cardiovascular cause.
Source: Kloner et al., "The Association of Tadalafil Exposure With Lower Rates of Major Adverse Cardiovascular Events and Mortality," Clinical Cardiology (2024)
Linked to lower mortality
A separate study of over 72,000 men found PDE-5 inhibitor users had 25% lower overall mortality and 13% fewer major heart events than non-users.
Source: Kloner et al., Journal of Sexual Medicine (2023) & Andersson et al., Journal of the American College of Cardiology (2021)
Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of the referenced medication. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes or expected results.
HOW TADALAFIL WORKS
Opens blood vessels.
Supports circulation. Tadalafil works on one enzyme in your vascular system. This single action supports vascular health, sexual function, and longevity.
PDE5 inhibited
Tadalafil inhibits PDE5, the enzyme that breaks down cGMP, the chemical signal that keeps blood vessels relaxed.
cGMP preserved
cGMP can then stay active longer. This helps blood vessels stay relaxed which can help keep circulation running smoothly.
Step 1
Medical intake
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A few minutes
Step 2
Doctor review
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*
Within 72 hours
Step 3
Fast shipping
Approved medications ship directly to your door in discreet packaging.
2-5 business days
Step 4
Unlimited messaging
Your doctor is available via chat any time for additional support. Video consults available. The same prescription framework as REG3N's medical team. *Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
Up to 12 months
Proactive care
Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.
Transparent pricing
No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.
Board-certified doctors
Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.
Curated by longevity experts
Every protocol is built by medical experts, based on longevity research from REG3N's science team.
What is tadalafil?
Tadalafil (generic for Cialis®) is an FDA-approved PDE5 inhibitor prescribed for erectile dysfunction and benign prostatic hyperplasia. Some physicians also prescribe it off-label at low daily doses within longevity protocols.
How do you take tadalafil?
Tadalafil is a daily tablet, taken with or without food. It can be prescribed as-needed or daily. Your doctor determines the dosage based on your needs and medical history.
What are the side effects of tadalafil?
The most frequently reported side effects are headache, flushing, nasal congestion, and back pain. These are typically mild and tend to resolve as your body adjusts. Tell your doctor if side effects persist or feel disruptive.
Who shouldn't take tadalafil?
Tadalafil should not be taken with nitrate medications (used for chest pain or heart conditions), because the combination can cause dangerous drops in blood pressure. It is also not recommended for people with severe heart disease, recent heart attack or stroke, or severe liver or kidney problems. Your doctor will review your full medication list and health history before prescribing.
Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program.
Can help relax blood vessels, supporting sexual function, vascular health, and healthy aging.