- Product overview
- Why Tadalafil
- How it works
- Treatment process
- Explore other treatments
- Why REG3N
- Common questions
- Treatment information
Apomorphine/Tadalafil/Vardenafil
From $48/mo*
A 3-in-1 formulation of apomorphine, tadalafil, and vardenafil to support men’s sexual performance.
*Billed quarterly with a three-month commitment paid up front.
WHY TADALAFIL
Blood vessels tighten as you age. Tadalafil helps keep them open.
Supports better sex
In the 12-week US trial, men taking as-needed tadalafil successfully completed intercourse in 67.6% of attempts, compared to only 24.1% with placebo
Source: Seftel AD, Wilson SK, Knapp PM, et al. The Journal of Urology (2004)
Can improve erections
82.8% of tadalafil-treated men reported improved erections on the Global Assessment Question, versus 19.6% on placebo.
Source: Seftel AD, Wilson SK, Knapp PM, et al. The Journal of Urology (2004)
Trials show sustained results
Across 7 pivotal trials (>4,000 patients), as-needed tadalafil improved IIEF Erectile Function domain scores by +5.6 to +8.0 points
Tadalafil. FDA Drug Label. Food and Drug Administration. (2024)
Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of a medication class or active ingredient. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes. References to medication classes, mechanisms, or published studies are intended to illustrate general pharmacologic concepts and do not establish that any specific medication, formulation, or treatment program will produce identical results. Compounded medications are not evaluated by the FDA for safety, quality or efficacy.
HOW MEN’S SEX COMPLEX WORKS
Heightens arousal.
Improves performance. Apomorphine activates dopamine receptors in the brain which has been studied for enhancing sexual response. Tadalafil and vardenafil both block the PDE5 enzyme, which can help improve circulation to support erectile function.

Activates desire signals
Apomorphine stimulates dopamine receptors in the hypothalamus and limbic system, initiating the signals that drive sexual arousal independent of blood flow.
Preserves nitric oxide
With PDE5 inhibited, the nitric oxide signal lasts longer. Blood vessels stay relaxed and circulation stays open, supporting erectile response.
Inhibits PDE5
Tadalafil and vardenafil block PDE5, the enzyme that breaks down nitric oxide, the chemical signal that tells blood vessels to relax.
Step 1
Medical intake
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A few minutes
Step 2
Doctor review
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*
Within 72 hours
Step 3
Fast shipping
Approved medications ship directly to your door in discreet packaging.
2-5 business days
Step 4
Unlimited messaging
Your doctor is available via chat any time for additional support. Video consults available. The same prescription framework as REG3N's medical team. *Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
Up to 12 months
Proactive care
Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.
Transparent pricing
No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.
Board-certified doctors
Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.
Curated by longevity experts
Every protocol is built by medical experts, based on longevity research from REG3N's science team.
What is Men’s Sex Complex?
Men’s Sex Complex is an as-needed sublingual tablet taken 30 - 60 minutes before sex. It contains apomorphine, tadalafil, and vardenafil, which can support erectile response and sexual performance.
How do you take Men’s Sex Complex?
Dissolve half to one full tablet under the tongue or in the cheek 30 to 60 minutes before sexual activity. Not intended for daily use. Use only as needed.
What are the side effects of Men’s Sex Complex?
Side effects may include headache, flushing, nasal congestion, dizziness, lightheadedness, and nausea.
Who shouldn’t take Men’s Sex Complex?
Men’s Sex Complex cannot be taken with nitrates, or by people with unstable cardiovascular disease. Your doctor will evaluate if Men’s Sex Complex is appropriate for you.
Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program.
A 3-in-1 formulation of apomorphine, tadalafil, and vardenafil to support men’s sexual performance.





