Metformin
- Product overview
- Why Metformin
- How it works
- Treatment process
- Explore other treatments
- Why REG3N
- Common questions
- Treatment information
From $20/mo*
Activates AMPK, the body’s cellular energy switch, supporting steadier blood sugar, metabolic health, and longevity.
*Billed quarterly with a three-month commitment paid up front.
WHY METFORMIN
Metformin may target pathways linked to biological aging.
GPD1 Pathway
Researchers found that genetic mimicry of metformin's GPD1 target was associated with a biological age equivalent approximately 5.3 years younger.
Source: Luo et al., "Effects of Putative Metformin Targets on Phenotypic Age and Leukocyte Telomere Length," The Lancet Healthy Longevity (2023)
PhenoAge
In a study of over 300,000 people, metformin users had a biological age 0.36 years younger than non-users — measured by PhenoAge, a blood-based marker of how fast the body is aging internally.
Source: Luo et al., "Effects of Putative Metformin Targets on Phenotypic Age and Leukocyte Telomere Length," The Lancet Healthy Longevity (2023)
AMPKγ2
Another metformin-related pathway, AMPKγ2, was associated with a biological age equivalent approximately 4.9 years younger.
Source: Luo et al., "Effects of Putative Metformin Targets on Phenotypic Age and Leukocyte Telomere Length," The Lancet Healthy Longevity (2023)
Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of the referenced medication. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes or expected results.
HOW METFORMIN WORKS
Activates AMPK.
Mimics fasting. Metformin works on an energy-sensing pathway in your cells. This can support: blood sugar control, cellular aging, and metabolic health.
Activates AMPK
Metformin activates AMPK, a cellular switch that turns on when energy runs low. When it's on, the body shifts into repair mode, using energy more efficiently and reducing excess glucose production.
Reduces glucose
Metformin can reduce the liver's tendency to release sugar into the bloodstream between meals. The result is steadier blood sugar throughout the day and less strain on insulin production.
Suppresses mTOR
AMPK activation signals the body to dial back mTOR, the pathway that drives cell growth. Keeping mTOR in check is associated with slower cellular aging, and mirrors what the body does during caloric restriction.
Step 1
Medical intake
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A few minutes
Step 2
Doctor review
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*
Within 72 hours
Step 3
Fast shipping
Approved medications ship directly to your door in discreet packaging.
2-5 business days
Step 4
Unlimited messaging
Your doctor is available via chat any time for additional support. Video consults available. The same prescription framework as REG3N's medical team. *Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
Up to 12 months
Proactive care
Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.
Transparent pricing
No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.
Board-certified doctors
Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.
Curated by longevity experts
Every protocol is built by medical experts, based on longevity research from REG3N's science team.
What is metformin?
Metformin is an FDA-approved medication for type 2 diabetes. Off-label, doctors sometimes prescribe it within a longevity framework given growing evidence of its effects on the cellular pathways associated with biological aging.
How do you take metformin?
Metformin is an oral tablet taken with meals. Always follow the dosage instructions from your doctor.
What are the side effects of metformin?
Common side effects include nausea, loose stools, and stomach discomfort, especially in the first few weeks. These should settle as your body adjusts. Contact your doctor if side effects are persistent or bothersome.
Who shouldn't take metformin?
Metformin is not recommended for people with severe kidney impairment, a known hypersensitivity to metformin, or acute metabolic acidosis including diabetic ketoacidosis. Extra caution applies to patients over 65 and those scheduled for imaging procedures using iodinated contrast. Your doctor will review your kidney function and full health history before prescribing.
Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program.
Activates AMPK, the body’s cellular energy switch, supporting steadier blood sugar, metabolic health, and longevity.