Peptide Skin Complex (4-in-1)
- Product overview
- Why Tretinoin
- How it works
- Treatment process
- Explore other treatments
- Why REG3N
- Common questions
- Treatment information
Tretinoin with Niacinamide/Caffeine/Copper Tripeptide
From $133/mo*
A 4-in-1 topical cream including tretinoin, caffeine, copper tripeptide, and niacinamide. Helps reduce fine lines, fade dark spots, rebuild collagen, and brighten skin tone.
*Billed quarterly with a three-month commitment paid up front.
WHY TRETINOIN
Increases skin cell turnover. Improves photoaged skin.
Supports sun-damaged skin
In a 6-month trial of nearly 300 adults with sun-damaged skin, 68% using tretinoin showed overall skin improvement.
Source: Olsen et al., "Tretinoin Emollient Cream: A New Therapy for Photodamaged Skin," Journal of the American Academy of Dermatology (1992) & Stern, "Treatment of Photoaging," New England Journal of Medicine (2004)
Published study facts
Helps reduce fine wrinkles
The trial found tretinoin was effective at reducing fine wrinkles, uneven brown spots (mottled hyperpigmentation), and rough skin texture.
Source: Olsen et al., "Tretinoin Emollient Cream: A New Therapy for Photodamaged Skin," Journal of the American Academy of Dermatology (1992) & Stern, "Treatment of Photoaging," New England Journal of Medicine (2004)
Demonstrates 2x improvements
Across multiple similar trials, the rate of improvement with tretinoin was roughly double that of placebo.
Source: Olsen et al., "Tretinoin Emollient Cream: A New Therapy for Photodamaged Skin," Journal of the American Academy of Dermatology (1992) & Stern, "Treatment of Photoaging," New England Journal of Medicine (2004)
Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of the referenced medication. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes or expected results.
HOW PEPTIDE SKIN COMPLEX WORKS
Rebuilds skin at every layer.
Tretinoin stimulates collagen production and reduces pigmentation, caffeine provides antioxidant defense. Copper tripeptide can improve skin elasticity. Niacinamide may even skin tone at the surface.
Accelerates skin cell turnover
Dead skin cells shed faster. New cells reach the surface more quickly, improving texture and tone.
Improves complexion
Can reduce melanin production, and redness, fading dark spots and brightening out skin tone.
Stimulates collagen production
Fibroblasts are activated, producing new collagen, and helping reverse structural damage from UV exposure.
Step 1
Medical intake
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A few minutes
Step 2
Doctor review
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*
Within 72 hours
Step 3
Fast shipping
Approved medications ship directly to your door in discreet packaging.
2-5 business days
Step 4
Unlimited messaging
Your doctor is available via chat any time for additional support. Video consults available. The same prescription framework as REG3N's medical team. *Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
Up to 12 months
Proactive care
Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.
Transparent pricing
No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.
Board-certified doctors
Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.
Curated by longevity experts
Every protocol is built by medical experts, based on longevity research from REG3N's science team.
What is Peptide Skin Complex (4-in-1)?
Peptide Skin Complex contains caffeine, Copper tripeptide, tretinoin, and niacinamide in one topical cream. It can target hyperpigmentation, fine lines, and uneven texture.
How do you use Peptide Skin Complex?
Cleanse face and neck thoroughly and pat dry. Apply a thin layer of Peptide Skin Complex to affected areas or entire face once daily in the evening as prescribed. Tretinoin increases sensitivity to the sun. Always follow with a broad-spectrum sunscreen during the day.
What are the side effects of Peptide Skin Complex?
Common side effects include mild redness or irritation, dryness, peeling, burning, and sensitivity.
When to expect results?
Meaningful improvements in collagen and texture typically take 3–6 months of consistent use. Stopping too early is the most common reason people don't see results.
Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program.
A 4-in-1 topical cream including tretinoin, caffeine, copper tripeptide, and niacinamide. Helps reduce fine lines, fade dark spots, rebuild collagen, and brighten skin tone.