NAD+ (Nasal Spray)
- Product overview
- Why Nad+
- How it works
- Treatment process
- Explore other treatments
- Why REG3N
- Common questions
- Treatment information
From $119/mo*
Can replenish NAD+ levels, which naturally decline with age. Supports cellular energy, DNA repair, and antioxidant defense.
*Billed quarterly with a three-month commitment paid up front.
WHY NAD+
NAD+ declines with age. Supplementing can help replenish it.
NAD+ drops with age
NAD+ levels drop steeply with age. Direct measurements in human tissue found levels of 8.5 units at birth, 2.7 units in young adults, and just 1.1 units in people over 71 — an 87% decline over a lifetime.
Source: Massudi et al., "Age-Associated Changes in Oxidative Stress and NAD+ Metabolism in Human Tissue," PLoS ONE (2012); Nakahata & Bessho, "The Circadian NAD+ Metabolism," BioMed Research International (2016)
Published study facts
Less NAD+ linked to less cellular repair
This decline matters because NAD+ fuels the enzymes that repair your DNA and protect your cells from damage — so as NAD+ falls, your cells become less able to maintain and repair themselves.
Source: Massudi et al., "Age-Associated Changes in Oxidative Stress and NAD+ Metabolism in Human Tissue," PLoS ONE (2012); Nakahata & Bessho, "The Circadian NAD+ Metabolism," BioMed Research International (2016)
Published study facts
Men see steeper NAD+ decline
In a study of over 1,500 people, men over 60 had roughly 2 μmol/L lower NAD+ levels than men under 30. Women showed no significant decline with age, suggesting the NAD+ gap is more pronounced in men.
Source: Yang et al., "Association of Human Whole Blood NAD Contents With Aging," Frontiers in Endocrinology (2022); Jadeja et al., "Implications of NAD+ Metabolism in the Aging Retina," Oxidative Medicine and Cellular Longevity (2020)
Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of a medication class or active ingredient. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes. References to medication classes, mechanisms, or published studies are intended to illustrate general pharmacologic concepts and do not establish that any specific medication, formulation, or treatment program will produce identical results. Compounded medications are not evaluated by the FDA for safety, quality or efficacy.
HOW NAD+ WORKS
Powers cells.
Activates repair. NAD+ is a coenzyme that cells use to turn nutrients into energy. It fuels two enzyme families — sirtuins and PARPs — that regulate DNA repair, inflammation, and aging processes.
Supports cellular health
NAD+ fuels cellular energy and supports antioxidant defense. Subcutaneous delivery can replenish NAD+ levels and support healthy cellular function as those levels decline with age.
Activates repair pathways
Sirtuins and PARPs (enzyme families that depend on NAD+) help repair damaged DNA, regulate inflammation, and influence the processes linked to cellular aging.
Fuels energy production
NAD+ converts nutrients into ATP (Adenosine Triphosphate), the energy source that powers every living cell.
Step 1
Medical intake
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A few minutes
Step 2
Doctor review
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*
Within 72 hours
Step 3
Fast shipping
Approved medications ship directly to your door in discreet packaging.
2-5 business days
Step 4
Unlimited messaging
Your doctor is available via chat any time for additional support. Video consults available. The same prescription framework as REG3N's medical team. *Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
Up to 12 months
Proactive care
Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.
Transparent pricing
No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.
Board-certified doctors
Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.
Curated by longevity experts
Every protocol is built by medical experts, based on longevity research from REG3N's science team.
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of the body. It plays a role in energy production, DNA repair, and cellular metabolism.
How do you take NAD+?
Inject 10 units of NAD+ (Injections) three times a week for 1 week. Increase by 10 units weekly to a maximum dose of 50 units. For NAD+ (Nasal Spray), spray once or twice into each nostril one to two times daily.
What are the side effects of NAD+?
May include nausea, headache, dizziness, injection site reactions (for injections), nasal irritation (for nasal spray), and muscle tightening or cramping.
Who shouldn’t take NAD+?
People with a history or susceptibility to cancer should use with caution. Your doctor will evaluate whether NAD+ is appropriate for you.
Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program.
Can replenish NAD+ levels, which naturally decline with age. Supports cellular energy, DNA repair, and antioxidant defense.